“I think that in human evolution, it has never been as necessary to have this substance LSD. It is just a tool to turn us into what we are supposed to be.”

– Albert Hofmann


This month, I want to introduce Albert Hofmann. He not only synthesized LSD but is also responsible for synthesizing psilocybin and psilocin, which R. Gordon Wasson brought to Maria Sabina to try in Mexico. He is a legendary figure who greatly impacted our world and sparked a revolution in consciousness exploration and therapeutic research.


Maria Sabina


Hofmann, a Swiss chemist born on January 11, 1906, in Baden, Switzerland, left an indelible mark on the world through his groundbreaking discovery of LSD (Lysergic acid diethylamide). His life and work are significant not only in the realm of chemistry but also in the cultural and scientific exploration of psychedelics.

Hofmann’s journey into the world of psychedelics began in 1938 when he synthesized LSD-25 as part of his research into the medicinal properties of ergot alkaloids at the Sandoz Laboratories in Basel, Switzerland. However, it wasn’t until April 16, 1943, that he accidentally ingested a small amount of LSD, experiencing its powerful psychoactive effects firsthand. This event, known as Bicycle Day, marked the beginning of his profound relationship with psychedelics.



Despite the accidental nature of his first LSD experience, Hofmann approached the substance with scientific curiosity and rigor. He continued to study its effects, recognizing its potential applications in psychiatry and psychology. His research paved the way for further exploration into the therapeutic benefits of psychedelics, particularly in the treatment of mental health disorders such as depression and addiction.

Throughout his life, Hofmann remained an advocate for the responsible and controlled use of psychedelics. He believed that these substances had the potential to facilitate profound spiritual experiences and promote personal growth when used with respect and caution. However, he also cautioned against their recreational misuse, emphasizing the importance of set, setting, and dosage in ensuring safe and meaningful experiences.



Hofmann’s contributions to the field of psychedelics extended beyond the discovery of LSD. He also synthesized and investigated other psychoactive compounds, including psilocybin and psilocin, the active ingredients in magic mushrooms. His work laid the foundation for the psychedelic renaissance of the 21st century, sparking renewed interest in the therapeutic potential of these substances after decades of stigma and prohibition.

Despite facing criticism and controversy throughout his career, Hofmann remained steadfast in his belief in the positive potential of psychedelics. He continued to advocate for their scientific study and responsible use until his death on April 29, 2008, at the age of 102.

Today, Albert Hofmann’s legacy lives on through the ongoing research into psychedelics and their therapeutic applications. His pioneering work has inspired a new generation of scientists, therapists, and enthusiasts to explore the profound mysteries of the psychedelic experience and its potential to heal and transform lives.